During an acute infection, which of the following is UNLIKELY to occur?

• A. An increase in the total white cell count
• B. Fever
• C. Local redness at infection site
• D. A decrease in the total white cell count

Answer: (D)

During an acute infection the body mounts an inflammatory and immune response. The bone marrow responds by increasing production and release of white blood cells, especially neutrophils, so the total white cell count rises. Fever is triggered by pyrogens that raise the hypothalamic set point, leading to higher body temperature. Local redness at the infection site results from inflammation-driven vasodilation and increased blood flow bringing immune components to the area. A decrease in the total white cell count would not fit this active mobilization; it would suggest bone marrow suppression or a different, more severe scenario rather than a typical acute infection. So the statement describing a drop in white cell count is unlikely to occur.